Glucosamine and Chondroitin sulfate are essential component of joint tissue involved in the production of hyaluronic acid, which is important component of the synovial fluid that lubricates the joints, and a major component of the connective tissue in the skin. Methylsulfonylmethane (MSM) is an organic source of sulfur, an antioxidant mineral and critical component of structural body tissue such as cartilage. The sulfur from MSM is incorporated into joint tissue as glycosaminoglycans (or mucopolysaccharides) such as chondroitin sulfate and hyaluronic acid.